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hemH [2017-09-04 14:36:47]
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hemH [2017-09-04 14:36:47]

ferrochelatase, catalyzes the final step of heme b biosynthesis
locus
BSU10130
pI
4.62
mw
35.19 kDa
protein length
310 aa Sequence Blast
gene length
930 bp Sequence Blast
function
heme biosynthesis
product
ferrochelatase
essential
no
ec
4.99.1.1
synonyms
hemF
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.6|Biosynthesis of heme/ siroheme]

    • Gene

    Coordinates
    1,087,250 → 1,088,182

    The protein

    Catalyzed reaction/ biological activity

  • insertion of Fe(2+) into protoporphyrin IX

    • Protein family

  • ferrochelatase family (according to Swiss-Prot)

    • Structure

  • [PDB|2HK6] (complex with iron) [pubmed|17198378]
  • [PDB|1AK1] [pubmed|9384565]

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    genes
    [gene|762E7731EFEAC9F38074D7A7E9A3E5759437CDCA|hemE]-[gene|E4C588EC93132CCBE4F40559F8A480A66A2D82D7|hemH]-[gene|7541AD7D06BC4CE30AD576562E0053CC1E25B4D6|hemY]
    description
    [Pubmed|1459957]
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    References

  • 9384565,1459957,8119288,21052751,23097001,16453119,25826316,28864672,17198378,9384565,12761666,10704318,25646457